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ESC Guidelines Give Top Recommendation to CRT for Mild Heart Failure
An update to the European guidelines for use of device therapy in heart failure extends its strongest, most evidence-based recommendation--class I, level of evidence A--for use of cardiac resynchronization therapy (CRT) from the traditional NYHA class 3–4 indication to include patients with "mild" NYHA class 2 heart failure [1].
The class I A recommendation in NYHA 2 heart failure, for curtailing disease progression rather than "morbidity or mortality reduction" as allowed in NYHA 3–4, is based on the randomized, controlled REVERSE and especially MADIT-CRT studies, which--as previously covered by heartwire --included NYHA class 1–2 patients and saw CRT significantly improve HF hospitalization or death and HF-free survival, respectively.
More at Medscape
The class I A recommendation in NYHA 2 heart failure, for curtailing disease progression rather than "morbidity or mortality reduction" as allowed in NYHA 3–4, is based on the randomized, controlled REVERSE and especially MADIT-CRT studies, which--as previously covered by heartwire --included NYHA class 1–2 patients and saw CRT significantly improve HF hospitalization or death and HF-free survival, respectively.
More at Medscape
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