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No MI, Mortality Threat From Echo Contrast Agents in Meta-Analysis
August 13, 2010 (Detroit, Michigan) — A meta-analysis of eight controlled studies found no significant elevation in risk of MI or mortality in patients who received echocardiographic contrast agents [1], supporting other evidence that they are generally safe for their approved indications despite "black-box" safety cautions in their labeling.
"Some of the studies had weak signals one way or another, but they didn't reach significance. When we combined them and had thousands and thousands of patients [for analysis], we did not see any signal that echo contrast was causing any harm," senior author Dr Mouaz H Al-Mallah (Henry Ford Health System, Detroit, MI and King Abdul-Aziz Medical City, Riyadh, Saudi Arabia) told heartwire.
More at Medscape
"Some of the studies had weak signals one way or another, but they didn't reach significance. When we combined them and had thousands and thousands of patients [for analysis], we did not see any signal that echo contrast was causing any harm," senior author Dr Mouaz H Al-Mallah (Henry Ford Health System, Detroit, MI and King Abdul-Aziz Medical City, Riyadh, Saudi Arabia) told heartwire.
More at Medscape
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